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Most strikingly, late-life-initiated intermittent treatment—started at 23.5 months, the murine equivalent of late human life—increased physical capacity and healthspan.2 Lee noted: “As we age, that communication network seems to break down, but our study suggests you can restore that network or rejuvenate an older mouse so it is as fit as a younger one.” A December 2024 study from Shanghai University of Sport tested serum MOTS-c levels in marathon runners versus sedentary subjects, finding a close association between circulating MOTS-c and aerobic exercise capacity